Otto Louis-Jacques, M.D.

11502 Alma Street

Silver Spring, MD 20902

Business Address:                         Pediatric Specialists of Virginia

                                                      3023 Hamaker Court, Suite 600

                                                      Fairfax, VA 22031

                                                      Tel: 703-876-2788

Professional Practice                 

3/2020-present                        Children’s National Medical Center

10/2014-present                      Pediatric Specialists of Virginia

10/2006-9/2014                      Inova Health Care Services

2/2003-10/2006                      Gastroenterology Associates of Northern Virginia

Academic appointments

8/1996-1/2003                        Assistant Professor

                                                      Department of Pediatrics

                                                      University of Maryland, Baltimore

                                                      Baltimore, Maryland

Education

10/80-5/89                              M.D.

                                                      Faculté des Sciences Médicales et Pharmaceutiques

                                                      Université d'Angers

                                                      Angers, France

10/92-6/93                              Statistics in Medicine Diploma, option Clinical Research

                                                      Center for the Study of Statistics in Medicine and Biology

                                                      Université Pierre et Marie Curie (Paris VI)

                                                      Villejuif, France

09/97-05/00                            M.S. Epidemiology and Preventive Medicine                                      

                                                      University of Maryland, Baltimore

                                                      Baltimore, Maryland

Post-graduate Training

11/89-11/92                            Residency, Pediatrics

                                                      Cook County Hospital

                                                      Chicago, Illinois

7/92-6/93                                Chief Resident, Pediatrics

                                                      Cook County Hospital

                                                      Chicago, Illinois  

7/93-6/96                                Fellowship, Pediatric Gastroenterology

                                                      University of Michigan Medical Center

Certifications

7/88                                         FMGEMS (ECFMG certificate issued 4/89)

12/90                                       FLEX

12/93                                       Pediatrics, American Board of Pediatrics

8/97                                         Pediatric Gastroenterology, American Board of Pediatrics     

Licenses                           

                                                      M.D.                      Maryland # D0051044

                                                                                    Michigan # 431062382

                                                                                    Illinois # 036-083882 (Inactive Status)

                                                                                    Virginia # 0101233886

                                                                                    District of Columbia #MD 047961

Honors and Awards

Very Honorable Mention with Congratulations from Thesis Committee (highest honors) for Medical Doctorate thesis: “Familial Tall Stature. A Study of 29 Cases” (Grande Taille Familiale. Etude de 29 observations.), Angers, France, May 1989.

Honorable (Assez Bien) Mention for Statistics in Medicine diploma, Clinical Research Option, Villejuif, France, 1993.

Professional Memberships

1989-1997                               American Academy of Pediatrics

1993-present                           North American Society for Pediatric Gastroenterology

                                                         and Nutrition

1997-2006                               American Gastroenterology Association

Publications

Louis-Jacques O, Olson AD.  Cost-benefit analysis of interferon therapy in children with chronic active hepatitis B.  J Pediatr Gastroenterol Nutr 1997;24:25-32.

Ibitayo AI, Sladick J, Tuteja S, Louis-Jacques O, Yamada H, Groblewski G, Welsh M, Bitar KN.  HSP27 in signal transduction and association with contractile proteins in smooth muscle cells.  Am J Physiol 1999;277:445-454.

Louis-Jacques O, Perman JA. Disorders of the stomach and duodenum in children. Cur Opi Gastroenterol 1999;15:516-520.

Louis-Jacques O, Perman JA. Disorders of the stomach and duodenum in children. Cur Opi Gastroenterol 2000;16:522-526.

Louis-Jacques O, Perman JA. Gastroduodenal disorders in children. Cur Opi Gastroenterol 2001;17:513-517.

Catassi C, Kryszak D, Louis-Jacques O, Duerksen DR, Hill I, Crowe SE, Brown AR, Procaccini NJ, Wonderly BA, Hartley P, Moreci J, Bennett N, Horvath K, Burk M, Fasano A.  Detection of celiac disease in primary care: a multicenter case-finding study in North America.  Am J Gastroenterol. 2007 Jul;102:1454-60.

   Ta A, Hourigan S, Louis-Jacques O. Internal biliary fistula secondary to Cushing’s ulcer in a child. Practical Gastroenterology 2017;41:40-43.

Louis-Jacques O. Foreign body ingestion of a soda can tab. Gastroenterology Consultant 2018;58:43-45.

https://www.consultant360.com/articles/foreign-body-ingestion-beverage-can-tab

Abstracts, Scientific Presentations

Louis-Jacques O, Olson AD. Cost-effectiveness analysis of interferon alpha 2b therapy in children with chronic active hepatitis B.  Gastroenterology, 1995,108:A1114.  Presented at the American Gastroenterological Association, May 1995.

Yamada H, Sbrissa D, Louis-Jacques O, Hajra A, Bitar KN.  Ceramide-induced, protein kinase C mediated contraction in smooth muscle cells from rabbit colon is through mitogen activated protein (MAP) kinase kinase (MEK) activation of MAP kinase.  Gastroenterology, 1995,108:A711.  Presented at the American Gastroenterological Association, May 1995.

Olson AD, Deutsch DD, Louis-Jacques O, Fendrick AM, Chernew ME, Hirth RA, Bloom BS. Clinical and economic analysis of immediate endoscopy, serological screening for H. pylori and empiric treatment of H. pylori for pediatric patients with dyspepsia.  Presented at the American Gastroenterological Association, May 1995.

Louis-Jacques O, Olson AD.  Cost-effectiveness analysis of interferon therapy in children with chronic active hepatitis B.  Presented at the Pediatric Research Symposium, University of Michigan, Ann Arbor, Michigan, September 1995.

Olson A, Louis-Jacques O.  The effect of HMO disenrollment on the cost-effectiveness of a hepatitis B vaccination program.  Gastroenterology, 1996,110:A32.  Presented at the American Gastroenterological Association, May 1996.

Louis-Jacques O, Gilmont R, Sladick J, Bitar KN.  Vasoactive intestinal peptide (VIP) inhibits bombesin-induced phosphorylation and translocation of heat shock protein 27 during smooth muscle contraction in rabbit colon.  Gastroenterology, 1996,110:A709.  Presented at the American Gastroenterological Association, May 1996.

Louis-Jacques O, Yamada H, Sladick J, Bitar KN.  Vasoactive intestinal peptide (VIP) inhibits contraction mediated by Raf-MAP kinase kinase (MEK) activation of MAP kinase in isolated smooth muscle cells from rabbit colon.  Gastroenterology, 1996,110:A710.  Presented at the American Gastroenterological Association, May 1996.

Olson A, Louis-Jacques O. The effect of differential immunization rates and HMO disenrollment on the cost effectiveness of a hepatitis B vaccination program.  Gastroenterology, 1997,112:A33.  Presented at the American Gastroenterological Association, May 1997.

Olson A, Turke P, Louis-Jacques O.  Screening for gluten enteropathy. A comparison of a multiple antibody panel versus anti-endomysial antibody alone. Gastroenterology, 1997,112:A33.  Presented at the American Gastroenterological Association, May 1997.

Louis-Jacques O, Olson A. Cost-effectiveness analysis of a universal immunization program against hepatitis A. J Pediatr Gastroenterol Nutr 1998, 26:580.  Presented at the 5^th Joint Meeting European Society for Paediatric Gastroenterology Hepatology and Nutrition-North American Society for Pediatric Gastroenterology and Nutrition, May 1998.

Olson AD, Louis-Jacques O, Rosenthal P. Living donor liver transplants in children and adults: an epidemiologic study of the Unos database. J Pediatr Gastroenterol Nutr 2000,32 (Suppl 2): S265. Presented at the World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition, August 2000.

Olson AD, Louis-Jacques O, Rosenthal P. Liver transplantation in children and adults: an epidemiologic study of the Unos database.  J Pediatr Gastroenterol Nutr 2000,32 (Suppl 2): S265. Presented at the World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition, August 2000.

Catassi C, Louis-Jacques O, Kryszak D, Horvath K, Medeiros L, Hill I, Duerksen D et al. Celiac disease case-finding in primary care in North America: Preliminary results of a multicenter, prospective study. Gastroenterology, 2004,126:S1752.  Presented at the American Gastroenterological Association, May 2004

Alpan O, Louis-Jacques O, Enav B, Goker-Alpan O. Tissue oriented approach to eosinophilic esophagitis. Presented at the 28^th Symposium of the Collegium Internationale Allergologicum, Ischia, Italy, April 29 2010.

Louis-Jacques O, Loizou D, Enav B, Townsend S, Sejas C, Leon E, Leibowitz I, Alpan O.  Usefulness of allergy patch testing in children with eosinophilic esophagitis.  Presented at the Annual Meeting of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, October 2011. 

Loizou D, Louis-Jacques O, Enav B, Kim J, Lee P, Chao C, Duffy L, Leibowitz I, Kaushal S, Farwah A, Goker-Alpan O, Alpan O. Elucidating mechanisms of allergic inflammation in eosinophilic esophagitis. Presented at the Annual Meeting of the American Academy of Allergy, Asthma and Immunology, February 2013.

Louis-Jacques O, Alpan O, Loizou D, Townsend S, Noonan L, Loncar K, Tufano M.                        Effectiveness of test directed and empiric elimination diet in patients with eosinophilic esophagitis. Presented at the Annual Meeting of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, October 2015.

Ta A, Khan M, Hourigan S, Louis-Jacques O. Case of cholecystoenteric fistula secondary to duodenal ulcer in a child. Presented at the World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, October 2016.

Zahid F, Louis-Jacques O, Hourigan S. Isolated sigmoid stenosis with normal caliber rectum: an unusual presentation of Hirschsprung’s disease. Presented at the Annual Meeting of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, October 2018.

Spurr A, Zhu W, Wong W, Diez B, Tufano B, Leibowitz I, Louis-Jacques O, Provenzano M, Zacharias K, Clemency N, Vilboux T, Niederhuber J, Hourigan S. The impact of gastric acid suppression on the developing intestinal microbiome of a child. Presented at the Annual Meeting of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, October 2018.

Nelson CL, Oliver K, Becker R, Hourigan S, Felix G, Louis-Jacques O. Association of esophageal pseudodiverticula and eosinophilic esophagitis in a child. Presented at the Annual Meeting of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, October 2019.

Falsey A, Louis-Jacques O, Nath B. Ingestion of multiple rare earth magnets. A sticky endoscopic challenge. Presented at the Annual Meeting of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, November 2020.

Abdelghani A, Sheridan MJ, Louis-Jacques O. Duration of remission and recurrence in                                   patients with proton pump inhibitor-responsive eosinophilic esophagitis. Presented at the Annual Meeting of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, November 2022.

Presentations

Inflammatory bowel disease in children. Pediatric CME course, Towson, Maryland.

Recurrent abdominal pain in children in the era of Helicobacter pylori. Pediatric CME, Towson, Maryland, November 1998.

Gastrointestinal manifestations of cystic fibrosis.  Grand Rounds, Department of Pediatrics, Mercy Hospital, Baltimore, Maryland, October 15, 1999.

Inflammatory bowel disease in children.  Grand Rounds, Department of Pediatrics, University of Maryland, Baltimore, Maryland, October 11, 2001.

Viral hepatitis. A primer. Grand Rounds, Department of Pediatrics, University of Maryland, Baltimore, Maryland, February 7, 2002.

Celiac Disease.  Grand Rounds, Department of Pediatrics, Holy Cross Hospital, Silver Spring, Maryland, April 2005.

Pediatric gastroesophageal reflux: Diagnosis and management.  Department of Pediatrics, Frederick Memorial Hospital, Frederick, Maryland, January 4, 2006.

Biliary atresia and neonatal jaundice.  Finding the needle in the haystack.  Grand Rounds, Department of Pediatrics, Inova Fairfax Hospital, Fairfax, Virginia, January 12, 2006.

Gastroesophageal Reflux in Infants and Children.  Diagnosis and Management.  Washington Adventist Hospital, Takoma Park, Maryland, March 3, 2006.

Inflammatory Bowel Disease in Children. Grand Rounds, Inova Alexandria Hospital, August 20, 2010.

Eosinophilic esophagitis.  Pediatric Grand Rounds, Shady Grove Adventist Hospital, March 13, 2012.

Quality of life aspects of eosinophilic esophagitis. Washington Area Eosinophilic Connection support group meeting. March 14, 2014.

Gastrointestinal emergencies in children and adolescents. Grand Rounds, Inova Alexandria Hospital, May 2, 2014.

Inflammatory bowel diseases in Children. Department of Pediatrics, State University Hospital, Port-au-Prince, Haiti, February 1, 2018.

Gastrointestinal bleeding in children. Department of Pediatrics, State University Hospital, Port-au-Prince, Haiti, February 2, 2018.

Inflammatory bowel disease in Children. Virginia Association of Physician Assistants Fall Meeting. November 3, 2018.

Feeding disorders in children. Fairfax Pediatrics, Fairfax, VA. December 4, 2018.

Functional Abdominal Pain in Children. Presented to community pediatricians. Tysons, VA. June 18, 2019.

Eosinophilic esophagitis during the coronavirus pandemic. Primary Care Specialty Lunch and Learn series. Children’s National Medical Center. Videoconference. May 27, 2020.

Updates on H pylori, eosinophilic esophagitis. PSV Grand Rounds. Videoconference. August 14, 2020.

Research Activities

Identification of immune markers in Gastrointestinal Eosinophilic Disease. Alpan O, PI; Louis-Jacques, O, sub-investigator. Closed

Milk Protein Intolerance in Infants. Leibowitz I, PI; Louis-Jacques O, sub-investigator. Closed

The E3 Healthcare Study (Engaged, Empowered, Electronic). Leibowitz I, PI; Louis-Jacques O, sub-investigator. Closed

Pediatric PROMIS (Patient Reported Outcomes Measurement Information System): IBD Clinical Evaluation. Duffy L, PI; Louis-Jacques O, sub-investigator. Closed

Adalimumab Effectiveness in Anti-TNF Naïve Pediatric Patients. Leibowitz I, PI; Louis-Jacques O, sub-investigator. Closed

HARMONY: A multi-center, long-term safety, efficacy and pharmacokinetics study of lubiprostone in paediatric patients age 6 years to less than 18 years with functional constipation. Chao C, PI; Louis-Jacques O, sub-investigator. Closed

IBEASE: Does a self-managed program using clinical hypnosis to treat functional abdominal pain/irritable bowel syndrome help children who failed conventional medical therapy? Chao C, PI; Louis-Jacques O, sub-investigator. Closed

The impact of gastric acid suppression on the developing intestinal microbiome of a child. Spurr S, PI; Louis-Jacques O, sub-investigator. Closed.

GutNet – An artificial intelligence-based digital repository for histopathology-based interpretation of gastrointestinal and liver diseases in children. Hourigan S, PI; Louis-Jacques O, sub-investigator. Closed

DEVELOP: A Multicentre, Prospective, Long-Term, Observational Registry of Pediatric Patients with Inflammatory Bowel Disease. Leibowitz I, PI; Louis-Jacques O, sub-investigator.

CAPE: A Long-Term, Non-Interventional Registry to Assess Safety and Effectiveness of Humira® (Adalimumab) in Pediatric Patients with Moderately to Severely Active Crohn’s Disease (CD). Sikka N, PI; Louis-Jacques O, sub-investigator.

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Investigate the

Efficacy and Safety of Mongersen (GED-0301) for the Treatment of Adult and Adolescent Subjects with Active Crohn’s Disease. Lee P, PI; Louis-Jacques O, sub-investigator.

Database of pediatric patients with gastrointestinal disease. Louis-Jacques O, PI

Analysis of the effect of disease and of topical steroids on growth of children with eosinophilic esophagitis. Louis-Jacques O, PI.

Duration of remission and recurrence rate in patients with proton pump inhibitor-responsive eosinophilic esophagitis. Louis-Jacques O, PI. Closed

A Phase 3 Study of the Efficacy, Safety, and Pharmacokinetics of Ustekinumab as Open-label Intravenous Induction Treatment Followed by Randomized Double-blind Subcutaneous Ustekinumab Maintenance in Pediatric Participants with Moderately to Severely Active Crohn’s Disease. Louis-Jacques O, PI.

A Phase 3 Study of the Efficacy, Safety and Pharmacokinetics of Ustekinumab as Open-label Intravenous Induction Treatment Followed by Randomized Double-blind Subcutaneous Ustekinumab Maintenance in Pediatric Participants with Moderately to Severely Active Ulcerative Colitis. Louis-Jacques O, PI.

A Phase 3, Multicenter, Open-label, Basket, Long-term Extension Study of Ustekinumab in Pediatric Clinical Study Participants (2 to <18 Years of Age). Louis-Jacques O, PI.