Lecture Description: 

Dr. Claudia R. Morris will discuss the 25-year history of arginine therapy from bench to bedside in patients with sickle cell disease and vasoocclusive pain . The presentation will highlight mechanisms-of-action, pharmacokinetics, phase 2 and phase 3 clinical trials of a novel amino acid therapy that was awarded orphan designation status for the treatment of sickle cell disease from the FDA in May 2024. Challenges with current clinical trials design for sickle cell disease acute pain studies will also be highlighted together with future direction for the field.

Learning Objectives:

  1. List complications of sickle cell disease that are related to an arginine deficiency
  2. Describe evidence-based benefits of arginine therapy in sickle cell disease
  3. Describe challenges with current clinical trial designed in sickle cell disease that may be hindering drug development
Session date: 
10/08/2025 - 8:00am to 9:00am EDT
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  • 1.00 ACPE Pharmacist
    Children's National Hospital is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This program meets ACPE criteria for 1.00 contact hours.
  • 1.00 AMA PRA Category 1 Credit™
    Children’s National Hospital designates this Live activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
  • 1.00 ANCC
    Children’s National Hospital will provide 1.00 Nursing Contact Hours for this Live activity.
  • 1.00 APA
    Continuing Education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP Office maintains responsibility for the content of the programs. All confirmed participants will earn 1.00 CE credits upon successful completion of the learning event and evaluation.
  • 1.00 ASWB
    As a Jointly Accredited Organization, Children’s National Hospital is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. Regulatory boards are the final authority on courses accepted for continuing education credit. Social workers completing this course receive 1.00 continuing education credits.
    • 1.00 General
  • 1.00 Participation
    Successful completion of this continuing education activity.
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Faculty List: 
Speaker(s)

Claudia Morris, MD

has no relevant financial relationships to disclose at this time.